The rise of modern laser beauty relies on the selective photothermolysis theory proposed by Anderson and Parrish in 1983. The theory points out that according to the biological characteristics of different tissues, as long as the appropriate parameters (wavelength, pulse width, energy, etc.) are selected, the lesion site can be effectively treated while minimizing the damage to the surrounding normal tissues.

With the development of laser technology and clinical research in the past four decades, the safety and effectiveness of laser treatment have gradually been recognized by the public. Among many laser beauty products, the long pulse width 1064nm laser has received extremely high attention in recent years.

The 1064nm wavelength belongs to infrared light and can be absorbed by targets such as water, hemoglobin, melanin and collagen fibers in the dermis. Because of the special wavelength, the penetration is deeper, and the treatment is safer and more comfortable, the market popularity of the product has continued to increase in recent years.

Long pulse width laser is different from traditional Q-switched and picosecond lasers. Its pulse width is in the microsecond level, which can cause thermal damage to target cells, and the pulse width parameters are adjustable. Therefore, the product is suitable for a wide range of clinical applications.

The traditional clinical application of long pulse width 1064nm laser is concentrated in the fields of vascular diseases, acne, pigmentation, etc. With the clinical exploration in recent years, it has gradually expanded to the treatment of enlarged pores, lifting and anti-aging, skin collagen regeneration and other aspects.

So, for the majority of beauty seekers, what common needs can long pulse width 1064nm laser solve?

RED BLOOD VESSELS REMOVAL

RED BLOOD VESSELS REMOVAL

Red blood streaks on the face are also called facial capillary dilation. That is, the elasticity of the capillary wall is reduced, the fragility is increased, the blood vessels continue to expand unevenly or even rupture, resulting in redness of the facial skin. The dilated capillaries can be seen with the naked eye, often accompanied by red or purple spots, dots, lines or stars, etc., which is called telangiectasia.

Facial capillaries are mainly present in the dermis of the skin. The absorption peaks of oxygenated hemoglobin in tissues for lasers are 420nm, 540nm, and 580nm respectively, but the therapeutic effect of short-wavelength lasers will be affected by their penetration depth.

Image source: Dingxiangyuan

Note: The values in the figure are adjacent values

Another absorption peak range of hemoglobin: 800-1100nm, the wavelength of 1064nm just belongs to this peak range, and it is not easily absorbed by epidermal melanin, reducing the probability of epidermal damage, so it is suitable for the treatment of deeper telangiectasia.

Image source: Miyan

In 2014, the Journal of Chinese Aesthetic Medicine published an analysis of the clinical efficacy of long pulse width 1064nm Nd:YAG laser in the treatment of telangiectasia in rosacea. The study subjects were 150 patients with erythema and telangiectasia of the nose and cheeks. They were treated with long-pulse 1064nm Nd:YAG laser every 2 weeks from April 2010 to March 2013.

The final results showed that long-pulse 1064nm Nd:YAG laser had a good effect in treating erythema and telangiectasia of rosacea. After 4 treatments, the total effective rate reached 95.6%. At the same time, after multiple regular treatments, capillary regeneration was basically controlled, significantly reducing the chance of recurrence.

Table. Comparison of the effects of different treatment times (the number of skin lesions is the number of capillary dilation)

Figure. Comparison before and after treatment

(From left to right: before treatment, 3 times of treatment, 6 times of treatment)

TREAT ACNE

Treatment of acne

Acne is a common chronic inflammatory skin disease in dermatology. It often occurs in the face, back and other parts of the sebaceous glands of adolescents and even some adults. In mild cases, it manifests as acne and papules, and in severe cases, it can turn into pustules and cysts. The etiology and mechanism are relatively complex and not yet fully understood. It is currently believed to be mainly related to family inheritance, abnormal hair keratinization, increased sebum secretion, and infection caused by anaerobic Propionibacterium acnes colonization, and it is easy to relapse.

Therefore, the purpose of acne treatment is not only to remove skin lesions, but also to prevent the occurrence of sequelae.

Long pulse width 1064nm laser can penetrate the epidermis and reach deep skin, producing a unique light-biological effect, effectively killing anaerobic Propionibacterium acnes and inhibiting acne. At the same time, the 1064nm wavelength laser can also act on the sebaceous glands in the dermis, regulate sebum secretion, and reduce inflammatory reactions, thereby reducing the probability of adverse phenomena after treatment.

In November 2015, "Journal of Shandong University (Medical Edition)" published a research report on long pulse width 1064nm Nd:YAG laser, which discussed the clinical efficacy and safety of long pulse width 1064nm Nd:YAG laser in the treatment of recurrent moderate to severe acne with post-acne erythema.

Table. Comparison of the effective rate of skin lesion disappearance after 4 and 8 weeks of treatment

Figure. Comparison of acne patients before treatment (left) and after 8 treatments (right)

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The main manifestations of skin aging are the loss, degeneration and a series of complex physiological changes of collagen and elastic fibers. Photoaging, staying up late, smoking and drinking and other bad habits can also aggravate the loss of skin elasticity.

Currently, there are many treatments to improve skin sagging. Considering the recovery period and potential complications, more and more people are considering non-invasive, safe and effective treatments.

Studies have shown that when the dermis is heated to 50~52℃, it can trigger the tissue's damage repair mechanism and stimulate the formation of new collagen and elastin fibers. When the dermis temperature reaches 65℃, the collagen fibers will physically shrink and maintain the stability of hydrogen bonds between molecules, thereby making the elasticity of collagen polymers Increase, and stimulate the formation of new collagen fibers.

The long pulse width 1064nm laser can penetrate into the dermis and fascia layer to achieve deep facial tightening. At the same time, its pulse width can be adjusted to seconds to fully heat the dermis and the skin below, so that the heat has enough time to diffuse in the epidermis without damaging the epidermis.

In 2018, a study on the effect of long pulse width 1064nm Nd:YAG laser on facial wrinkles and relaxation was published in the well-known medical journal LIMS (Lasers in Medical Science).

Dadkhahfar et al. conducted randomized half-face control treatments of fractional Er:YAG laser and long pulse width 1064nm Nd:YAG laser on 25 patients with facial wrinkles and relaxation, with a total of 3 treatments, each with an interval of 3 months.

The treatment results showed that both lasers can significantly improve facial aging problems such as nasolabial wrinkles, skin sagging, and jawline sagging. Among them, the efficacy of long-pulse Nd:YAG laser is better than that of fractional Er:YAG laser, and the recovery period of long-pulse Nd:YAG laser is shorter.

Figure. Comparison before and after treatment
(Left face: long pulse width Nd:YAG laser: right face: Er:YAG laser a. before treatment: b. 3 months after treatment)

LARGE PORES

Large pores

Facial pores are visible openings of the sebaceous glands of the hair follicles. Facial pores are not fixed structures and are affected by a variety of factors. Current mainstream clinical studies believe that the possible causes of enlarged pores include exogenous (ultraviolet exposure, bad living habits, inappropriate skin care methods, etc.) and endogenous (gender, age, hormones, vigorous sebum secretion, hair follicle hypertrophy, etc.) factors.

In 2016, the American Society of Dermatologic Surgeons published a study titled "Facial Pores: Definition, Causes, and Treatment Options" that suggested that the main factors leading to enlarged pores include vigorous sebum secretion, decreased skin elasticity, and hair follicle hypertrophy.

In August 2022, the authoritative medical journal LIMS (Laser in Medical Science) published a comparative study report on the safety and effectiveness of long pulse width and non-ablative dot matrix in the treatment of enlarged facial pores. The report recruited 27 volunteers with pore percentiles below 50% and treated them with long pulse 1064nm Nd:YAG laser (LPNY) and 1565nm non-ablative fractional laser (NAFL) on both sides of the face.

The two lasers have similar therapeutic effects on large facial pores, and the number of pores has decreased significantly after treatment. On the side treated with long pulse Nd:YAG laser, the average number of facial pores decreased from 1183.3+520 before treatment to 920.5+392.7 at the follow-up 2 months after treatment. At the same time, the side effects of 1064nm long pulse laser are smaller than those of 1565nm non-ablative fractional laser. The only adverse reaction is transient mild erythema.

Fig. Comparison of pores and their distribution on both sides of the face before treatment and during follow-up

a. LPNY side before treatment; b. NAFL side before treatment;

c. LPNY treated side at 2-month follow-up;d. NAFL treated side at 2-month follow-up.

As we all know, removing red blood streaks, treating acne, tightening the skin, and shrinking pores are all photoelectric treatment projects with great market demand. By analyzing existing clinical studies, it is not difficult to find that: long pulse width 1064nm laser has adjustable parameters of pulse width and energy. By selecting appropriate pulse width and energy, photoelectric treatment of these indications can achieve good treatment effects and excellent safety.

At the same time, long-pulse 1064nm laser can not only stand alone in many treatments, but also be combined with other treatment methods to achieve more ideal treatment effects. For example: "Observation on the efficacy of intense pulsed light combined with long-pulse Nd:YAG laser in the treatment of facial telangiectasia" published in "Chinese Journal of Aesthetic Medicine" in 2019, "The effect of long-pulse 1064nm Nd:YAG and 2940nm Er:YAG laser combined with intraoral and skin treatment to improve nasolabial wrinkles" published in "Chinese Journal of Medical Aesthetics and Cosmetology" in 2020, and "Study on the treatment of post-inflammatory pigmentation with long-pulse 1064nm laser combined with red and blue light" published in "Mathematical Medicine" in 2022, etc., researchers have achieved more ideal treatment effects through combined treatment.

The core founding team of Suzhou Foremed Legend Medical Technology Co., Ltd. comes from well-known universities at home and abroad such as Peking University. Foremed Legend focuses on the design, research and development and application of high-end medical beauty optoelectronic equipment based on compliance and product strength. It is committed to becoming a leading enterprise in the field of global high-end medical beauty optoelectronic equipment, a provider of integrated diagnosis and treatment intelligent solutions, and a pioneer of medical beauty data integration platform.

Through tackling a series of underlying key technologies, Foremed Legend has independently developed a number of high-end medical devices, including picosecond laser therapy devices, long pulse laser therapy devices, intense pulsed light therapy devices, photoacoustic imaging skin detection devices, and cold air therapy devices, and continues to deepen the research and development of core product technologies, using better technical solutions to benefit the vast number of beauty seekers.

Adhering to the principle of technology for good, Foremed Legend will work with industry and ecological partners to bring more safe and effective medical beauty optoelectronic equipment and integrated diagnosis and treatment solutions to the global medical beauty market.